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当前位置:专家介绍 |
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| 姓名： |
韩丹翔 |
工作单位： |
中国科学院水生生物研究所 |
| 性别： |
女 |
出生日期： |
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| 所在区域： |
武汉 |
研究方向： |
藻类生物学与藻类生物技术 |
| 职务： |
研究员 |
职称： |
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| 学历： |
研究生 |
学位： |
理学博士 |
| 人才称号： |
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| 学术兼职： |
《Algal Research》杂志副主编, 副主编 |
| 联系方式： |
danxianghan@ihb.ac.cn |
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1997年-2001年 武汉大学 药学专业 理学学士
2001年-2006年 中国科学院水生生物研究所 水生生物学 理学博士 |
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2014-09~现在, 中国科学院水生生物研究所, 研究员
2010-01~2014-09,Arizona State University, Assistant Research Professor
2006-07~2009-12,Arizona State University, Postdoctoral Research Associate |
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1.能源微藻遗传改良, 主持, 院级, 2015-06--2017-04
2.微藻高附加值产品开发, 主持, 院级, 2015-06--2017-04
3.****专项, 主持, 市地级, 2014-09--2016-12
4.微藻合成次生类胡萝卜素的调控机制, 主持, 国家级, 2016-01--2019-12
5.****择优, 主持, 部委级, 2016-01--2018-12
6.探讨不同LED光源对微藻生长及生物合成油脂及高附加值产品的影响, 主持, 部委级, 2015-05--2017-08
7.小球藻蛋白合成调节, 主持, 部委级, 2017-01--2019-12
8.饵料微藻高密度培养, 主持, 院级, 2019-01--2019-12
9.用于水产饲料的藻种资源评价病虫害防治与收获工艺开发, 主持, 院级, 2018-01--2018-12
10.微藻生物岩藻黄素的藻种资源评价、病虫害防治和收获工艺技术, 主持, 院级, 2018-01--2018-12
11.药用单细胞真核微藻活性成分研究与规模化培养示范, 主持, 国家级, 2019-07--2024-06
12.三角褐指藻EPA全景代谢与调控网络解析及新型细胞工厂开发, 参与, 研究所（学校）, 2019-09--2021-08 |
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1.Functional divergence of diacylglycerol acyltransferases in the unicellular green alga Haematococcus pluvialis, Journal of Experimental botany, 2020, 通讯作者
2.Identification and Biotechnical Potential of a Gcn5-Related N-Acetyltransferase Gene in Enhancing Microalgal Biomass and Starch Production, Frontiers in Plant Science, 2020, 通讯作者
3.High-throughput fluorescence-activated cell sorting for cell wall-deficient microalgal mutants screening, Algal Research, 2020, 通讯作者
4.PGRL1 overexpression in Phaeodactylum tricornutum inhibits growth and reduces apparent PSII activity, Plant Journal, 2020, 第 4 作者
5.Microalgal plastidial lysophosphatidic acid acyltransferase interacts with upstream glycerol-3-phosphate acyltransferase and defines its substrate selectivity via the two transmembrane domains, Algal Research, 2020, 通讯作者
6.Unraveling enhanced membrane lipid biosynthesis in Chlamydomonas reinhardtii starchless mutant sta6 by using an electrospray ionization mass spectrometry-based lipidomics method, Journal of Oceanology and Limnology, 2019, 通讯作者
7.Metabolic plasticity of the starchless mutant of Chlorella sorokiniana and mechanisms underlying its enhanced lipid production revealed by comparative metabolomics analysis, Algal Research, 2019, 通讯作者
8.Solid Matrix-supported Supercritical CO2 Enhances Extraction of γ-linolenic Acid from the Cyanobacterium Arthrospira (Spirulina) platensis and Bioactivity Evaluation in Zebrafish, Marine Drugs, 2019, 通讯作者
9.Ultrahigh-cell-density heterotrophic cultivation of the unicellular green microalga Scenedesmus acuminatus and application of the cells to photoautotrophic culture enhance biomass and lipid production, Biotechnology and Bioengineering, 2019, 通讯作者
10.Two filamentous microalgae as feed ingredients improved flesh quality and enhanced antioxidant capacity and immunity of the gibel carp (Carassius auratus gibelio), Aquaculture Nutrition, 2019, 第 6 作者
11.Biosynthesis of Triacylglycerol Molecules with Tailored PUFA Profile in Industrial Microalgae, Molecular Plant, 2018, 第 8 作者
12.Metabolic remodeling of membrane glycerolipids in the microalga Nannochloropsis oceanica under nitrogen deprivation, Frontiers in Marine Science, 2017, 通讯作者
13.Raman-activated droplet sorting (RADS) for label-free high-throughput screening of microalgal single-cells, Analytical Chemistry, 2017, 第 8 作者
14.Characterization of type 2 diacylglycerol acyltransferase in Chlamydomonas reinhardtii reveals their distinct substrate specificities and function in triacylglycerol biosynthesis, Plant Journal, 2016, 第 2 作者
15.A new paradigm for producing astaxanthin from the unicellular green alga Haematococcus pluvialis., Biotechnology & Bioengineering, 2016, 通讯作者
16. Molecular mecahnisms for photosynthetic carbon partitioning into storage neutral lipids in Nannochloropsis oceanica under nitrogen-depletion conditions, Algal Research, 2015, 通讯作者
17.Cellular capacities for high-light acclimation and changing lipid profiles across life cycle stages of the green alga Haematococcus pluvialis, Plos One, 2014, 通讯作者
18.Choreography of transcriptomes and lipidomes in Nannochloropsis reveals the mechanisms of oleaginousness in microalgae, Plant Cell, 2014, 第 1 作者
19.Comparative analyses of lipidomes and transcriptomes reveal a concerted action of multiple defensive systems against photooxidative stress in Haematococcus pluvialis, Journal of Experimental Botany, 2014, 通讯作者
20.Astaxanthin in microalgae: Biosynthesis pathways, regulation and biotechnological applications, Algae, 2013, 第 1 作者
21.Phospholipid:diacylglycerol acyltransferase is a multifunctional enzyme involved in membrane lipid turnover and degradation while synthesizing triacylglycerol in the unicellular green microalga Chlamydomonas reinhardtii, Plant Cell , 2012, 第 1 作者
22.Effect of initial biomass density on growth and astaxanthin production of Haematococcus pluvialis in an outdoor photobioreactor, Journal of Applied Phycology, 2012, 第 2 作者
23.Susceptibility and protective mechanisms of motile and non-motile cells of Haematococcus pluvialis (Chlorophyceae) to photooxidative stress, Journal of Phycology , 2012, 第 1 作者
24.Carotenoid distribution in living cells of Haematococcus pluvialis (Chlorophyceae), Plos ONE, 2011, 第 3 作者
25.Photosynthetic carbon partitioning and lipid production in the oleaginous microalga Pseudochlorococcum sp. (Chlorophyceae) under nitrogen-limited conditions, Bioresource Technology, 2011, 第 2 作者
26.Inhibition of starch synthesis results in overproduction of lipids in starchless mutants of Chlamydomonas reinhardtii., Biotechnology and Bioengineering, 2010, 第 2 作者
27.Chlamydomonas starchless mutant defective in ADP-glucose pyrophosphorylase hyper-accumulates triacylglycerol, Metabolic Engineering, 2009, 第 2 作者
28.An evaluation of four phylogenetic markers in Nostoc: Implications for cyanobacterial phylogenetic studies at the intrageneric level, Current Microbiology , 2009, 第 1 作者
29.Mutations stabilize small subunit ribosomal RNA in desiccation-tolerant cyanobacteria Nostoc, Current Microbiology, 2007, 第 1 作者
30.Progress in Nostoc research and its application, High Technology Letters, 2004, 第 1 作者 |
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Guanqun Chen, Baobei Wang, Danxiang Han, Milton Sommerfeld, Yinghua Lu, Feng Chen andQiang Hu (2015) Molecular mechanisms of the coordination between astaxanthin and fatty acid biosynthesis in Haematococcus pluvialis (Chlorophyceae). The Plant Journal 81, 95-107
Baobei Wang, Zhen Zhang, Qiang Hu, Milton Sommerfeld, Yinghua Lu and Danxiang Han (2014) Cellular capacities for high-light acclimation developed in life cycle of the green alga Haematococcuspluvialis. PLoS One DOI: 10.1371/journal.pone.0106679
Yunho Gwak, Yong-sic Hwang, Baobei Wang, Minju Kim, JooyeonJeong, Choul-Gyun Lee, Qiang Hu, Danxiang Han & EonSeonJin (2014) Comparative analyses of lipidomes and transcriptomes reveals a concerted action of multiple defensive systems against photooxidative stress in Haematococcus pluvialis. Journal of Experimental Botany 65: 4317-4334 (Co-Corresponding Author)
Li, J., Han, D., Wang D., Ning, K., Jia, J., et al (2013) Choreography of transcriptomes and lipidomes of Nannochloropsis reveals the mechanisms of oleaginousness in microalgae. Plant Cell26: 1645-1665 (Co-First Author)
Wang, D., Ning, K., Li, J., Han, D., Wang H., et al (2014) Nannochloropsis phylogenome revealed evolution of microalgal oleaginous traits. Plos Genetics 10: e1004094
Han, D., Li, Y. & Hu, Q. (2013) Biology and commercial aspects of Haematococcus pluvialis. pp. 388-405. In: Richmond, A. & Hu, Q. (eds.): Handbook of Microalgal Culture, 2 edition, Wiley-Blackwell, West Sussex, UK.
Han, D., Deng, Z., Lu, F. & Hu, Z. (2013) Biology and biotechnology of edible Nostoc, pp. 433-444.In: Richmond, A. & Hu, Q. (eds.): Handbook of Microalgal Culture, 2 edition, Wiley-Blackwell, West Sussex, UK.
Li, Y., Chen, W., Shen, H., Han, D., Li, Y., Jones, H., Timlin JA.& Hu, Q. (2013) Basic culturing and analytical measurement techniques, pp.37-68. In: Richmond, A. & Hu, Q. (eds.): Handbook of Microalgal Culture, 2 edition, Blackwell Science Ltd., Oxford, UK.
Li, Y., Han, D., Yoon, K., Zhu, S., Sommerfeld, M. & Hu, Q. (2013) Molecular and cellular mechanisms for lipid synthesis and accumulation in microalgae: biotechnological implication, pp. 545-565.In: Richmond, A. & Hu, Q. (eds.): Handbook of Microalgal Culture, 2 edition, Wiley-Blackwell, West Sussex, UK.
Han, D., Li, Y. & Hu, Q. (2013) Astaxanthin in microalgae: Biosynthesis pathways, regulation and biotechnological applications. Algae 28: 131-147
Yoon, K.S., Han, D., Li, Y. Sommerfeld, M. & Hu Q. (2012) Phospholipid:diacylglycerolacyltransferase is a multifunctional enzyme involved in membrane lipid turnover and degradation while synthesizing triacylglycerol in the unicellular green microalga Chlamydomonasreinhardtii. Plant Cell 24: 3708-24 (Co-First Author)
Wang, J., Han, D., Sommerfeld, M. & Hu, Q. (2012) Effect of initial biomass density on growth and astaxanthin production of Haematococcuspluvialis in an outdoor photobioreactor.Journal of Applied Phycology DOI: 10.1007/S10811-012-9859-4
Han, D., Wang, J., Sommerfeld, M. & Hu, Q. (2012) Susceptibility and protective mechanisms of motile and non-motile cells of Haematococcuspluvialis (Chlorophyceae) to photooxidative stress.Journal of Phycology 48:693-705
Collins, A., Jones, H., Han, D., Hu, Beechem, T. &Timlin, J. (2011) Carotenoid distribution in living cells of Haematococcuspluvialis (Chlorophyceae).Plos ONE 6: e24302 DOI: 10.1371/journal.pone.0024302
Li, Y., Han, D., Sommerfeld, M. & Hu, Q. (2011) Photosynthetic carbon partitioning and lipid production in the oleaginous microalga Pseudochlorococcum sp. (Chlorophyceae) under nitrogen-limited conditions.Bioresource Technology 102: 123-9
Li, Y., Han, D., Hu, G., Sommerfeld, M. & Hu, Q. (2010) Inhibition of starch synthesis results in overproduction of lipids in starchless mutants of Chlamydomonasreinhardtii.Biotechnology & Bioengineering, 107: 258-68
Li, Y., Han, D., Hu, G., Dauville, D., Sommerfeld, M., Ball, S. & Hu, Q (2009) Chlamydomonasstarchless mutant defective in ADP-glucose pyrophosphorylase hyper-accumulates triacylglycerol. Metabolic Engineering 12: 387-91
Han, D., Fan, Y. & Hu, Z. (2009) An evaluation of four phylogenetic markers in Nostoc: Implications for cyanobacterial phylogenetic studies at the intrageneric level. Current Microbiology 58: 170-176 |
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1.PCT on Novel Pseudochlorococcum Species and Uses Therefore, 发明, 2010, 第 3 作者, 专利号: 2173854
2.雨生血球藻突变株及其应用, 发明, 2015, 第 1 作者, 专利号: 201510983423.40
3.一种用农杆菌介导对雨生红球藻进行基因转化的方法及其应用, 发明, 2015, 第 1 作者, 专利号: 201510994162.6
4.莱茵衣藻溶血性磷脂酸酰基转移酶及其基因和用途, 发明, 2015, 第 3 作者, 专利号: 201511001292.1
5.超临界CO2提取螺旋藻中脂类物质的方法, 发明, 2016, 第 2 作者, 专利号: 201610739457.3
6.一种微藻培养方法, 发明, 2016, 第 2 作者, 专利号: 201610791128.3
7.一种微藻异养培养方法（氨水调控pH和替代部分铵盐补氮）, 发明, 2016, 第 2 作者, 专利号: 201611137997
8.雨生红球藻破壁及虾青素提取方法, 发明, 2017, 第 3 作者, 专利号: 201710270196X
9.一种微藻快速生长突变体筛选方法及应用, 发明, 2017, 第 1 作者, 专利号: 201710355791.3
10.索罗金小球藻合成淀粉缺陷型突变株及其应用, 发明, 2017, 第 1 作者, 专利号: 201710286674.6
11.尖状栅藻合成淀粉缺陷型突变株及其应用, 发明, 2017, 第 1 作者, 专利号: 201710400736.1
12.一种小球藻chlorella zofingiensis异养高密度培养方法, 发明, 2019, 第 5 作者, 专利号: 20191013602.3
13.一种微藻细胞壁突变体的筛选方法, 发明, 2019, 第 1 作者, 专利号: 201910131605.7
14.螺旋藻γ-亚麻酸的新用途, 发明, 2019, 第 5 作者, 专利号: 201910215558.4
15.一种高产蛋白质小球藻的培养方法, 发明, 2019, 第 1 作者, 专利号: 201910389527.0
16.索罗金小球藻在改善鱼类健康状况的功能性饲料中的应用, 发明, 2019, 第 3 作者, 专利号: 201910427021.4
17.一种螺旋藻生物活性物质分级分离方法, 发明, 2020, 第 2 作者, 专利号: 202010682601.0
18.一种能特异性识别别藻蓝蛋白的人工结合蛋白及获取方法, 发明, 2020, 第 3 作者, 专利号: 202010683209.8
19.一种通过金藻发酵高效生产水溶性β-1,3-葡聚糖的方法, 发明, 2020, 第 5 作者, 专利号: 202010902426.1
20.半乳糖脂-半乳糖脂半乳糖基转移酶及其基因和应用, 发明, 2021, 第 1 作者, 专利号: 202110197943.8 |
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